Modern Pharmaceutics, Fifth Edition, Volume 2: Applications by Alexander T. Florence, Juergen Siepmann

By Alexander T. Florence, Juergen Siepmann

Quantity 2 discusses the purposes and techniques in complicated drug supply platforms, together with transdermal, pulmonary, and ocular routes. moreover, it describes the impression of the shift to personalised drugs within the fields of pharmaceutical biotechnology, pharmacogenomics, and nanotechnology.DELIVERY of substances through THE PULMONARY course - Covers the interplay among the actual chemistry of the formulations and administered debris with the anatomy of the bronchial and alveolar regionsPEDIATRIC AND GERIATRIC PHARMACEUTICS - Addresses the physiological adjustments, layout, and construction of formulations for every of those sufferer populationsBIOEQUIVALENCE overview - Covers how you can degree the bioequivalence of a similar drug in quick-release pill, pill, or sustained-release shape, in addition to branded and conventional systemsTARGET-ORIENTED supply platforms - Explores the demanding situations of designing supply structures that focus on particular websites within the physique and reason fewer unwanted effects via interplay with non-diseased tissues

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68. Tatard VM, Sindji L, Branton JG, et al. Pharmacologically active microcarriers releasing glial cell line—derived neurotrophic factor: survival and differentiation of embryonic dopaminergic neurons after grafting in hemiparkinsonian rats. Biomaterials 2007; 28:1978–1988. 69. Santini JT, Cima MJ, Langer R. A controlled-release microchip. Nature 1999; 397:335–338. 70. Wang PP, Frazier J, Brem H. Local drug delivery to the brain. Adv Drug Deliv Rev 2002; 54: 987–1013. 71. Li Y, Shawgo RS, Tyler B, et al.

New York: Plenum Press, 1974. 2. , ed. Controlled Release of Biologically Active Agents. New York: John Wiley, 1987. 3. Langer RS, Wise DL, eds. Medical Applications of Controlled Release, Vol 1: Classes of Systems. Boca Raton: CRC Press, 1984. 4. Grieg NH. Optimizing drug delivery to brain tumors. Cancer Treat Rev 1987; 14:1–28. 5. Abott NJ, Romero IA. Transporting therapeutics across the blood-brain barrier. Mol Med Today 1996; 2:106–113. 6. Langer R. Polymeric delivery systems for controlled drug release.

Upon rotation around the z-axis, each pixel describes a ring. Importantly, the size of the two-dimensional pixels is not uniform and chosen in such as way that the volume of all three-dimensional rings is equal. This assures that the number of cleavable polymer backbone bonds in a ring representing nondegraded polymer is similar in all rings. Thus, the probability at which such a ring degrades upon first contact with water is similar. Since it is not possible to predict that at which time point which polymer backbone bond is cleaved, and as this process is random, Monte Carlo simulations can be used to describe this phenomenon.

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