Fluid Bed Particle Processing by Hede P.D.

By Hede P.D.

Fluid mattress granulation within the kind of agglomeration and coating methods are vital unit operations used for plenty of reasons within the biochemical and pharmaceutical industries. even if being uncomplicated within the primary rules, such procedures are tricky to regulate and completely comprehend. during this textual content the strategies and rules of fluid mattress rainy granulation procedures are brought including an creation to the mechanical homes of processed granules. therefore, you'll be acquainted with the fundamental rules and idea inside of this crucial box on a bachelor or master-of-science point.

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5 and 4. An unambiguous velocity dependence has however not been determined yet due to severe problems in testing abrasive wear mechanisms without the influence of other types of destructive mechanisms. Instead another more widely proved relation for indentor analysis of abrasion has been suggested by Bika et al. 7) where Ai is the apparent area of indentor contact and F is the total applied indentor load. 7, Vabrasion is inversely dependent on both the fracture toughness Kc and the hardness H.

In other words it is a measure of granule resistance to crack propagation. Fracture toughness is typically measured on a macroscopic scale in a special indentation test in which a specimen containing a sharp crack of known length is subjected to an applied load F, which is increased during the course of the test until the specimen fails. com 40 Mechanical properties of granules and coating layer... 4) The fracture toughness Kc is defined as the magnitude of the stress intensity factor K at the point of crack extension (Leeds, 2005).

2002) report that the chance of adhesion of the coating layer to the core material increases with solute concentration and surface tension for a number of coating materials. Both are parameters that increase during coating droplet drying. The stronger the adhesion is, the more likely is the tendency of unwanted agglomeration however. In the pursuit of suppressing agglomeration tendency in coatings Nakano et al. (1999) have added small concentrations of widely used salts to an existing type of polymer coating HPMC (hydroxypropyl methyl cellulose).

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