By Eric C. Beyer, Viviana M. Berthoud (auth.), Andrew L. Harris, Darren Locke (eds.)
Connexins: A advisor is a realistic and important reference and textual content protecting a large scope of data in regards to the connexin relatives of membrane channel proteins. The editors and contributing authors intend for this state of the art paintings to be informative to scientists wishing to profit concerning the box, in addition to to people who are lively researchers during this quarter. Connexins: A advisor masterfully addresses particular wishes of the clinical neighborhood; it's a finished and understandable narrative of the uncommonly varied connexin box, making formerly hard-to-find details simply available, whereas additionally proposing intelligible insights into the wide experimental tools and conceptual frameworks essential to take pleasure in and comprehend the real roles that connexin channel proteins play in overall healthiness and disease.
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Extra resources for Connexins: A Guide
Sample text
In most cases the presence of morphological gap junctions could account for the coupling of cells, and in some cases represented the only identifiable intimate contact between coupled cells [27]. The current working assumption of the field is that structures defined by 2 Channel Structure 31 Fig. 3. Orthogonal edge view of a cardiac gap junction membrane two-dimensional (2D) crystal negatively stained with uranyl acetate. The cytoplasmic, lipid membrane, and extracellular gap regions are indicated by the letters C, M, and G, respectively.
C. M. id=302800. be/CMTMutations/. id=608804. seccion=mut_db&db=nonsynd& nonsynd=cx26mut. seccion=mut_db&db=nonsynd& nonsynd=cx31mut. seccion=mut_db&db=nonsynd& nonsynd=cx30mut. seccion=mut_db&db=nonsynd& nonsynd=cx43mut. While mutations of the gene for Cx43 (GJA1) associated with nonsyndromic deafness have been reported [103], they have not been confirmed. It has been suggested that the described mutations may have actually derived from amplification and sequencing of the pseudogene for CX43 [17].
Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Genomics. 2006;87:265–74. 22. Milks LC, Kumar NM, Houghten R, Unwin N, Gilula NB. Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations. EMBO J. 1988;7:2967–75. 23. Goodenough DA, Paul DL, Jesaitis L. Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions. J Cell Biol.