Chondroitin Sulfate: Structure, Role and Pharmacological by Nicola Volpi

By Nicola Volpi

CS is an unbranched, polydisperse, complicated glycosaminoglycan extracted and purified from numerous tissues. This polyanion is interacting with either plasma and cells, it can modulate many biochemical and physiologic strategies. as a result of the presence of sulfate teams in several quantities and found in a variety of positions, CS represents a really heterogeneous family members of polysaccharides. accordingly, the preparative procedure and the analytical thoughts are of paramount significance to supply CS with particular constitution and houses and of pharmaceutical grade.

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J. Biol. Chem. 276(45), 41527–41542. , Kim, W. , Lee, I. , Kim, Y. , and Imanari, T. (2003). Purification and characterization of dermatan sulfate from the skin of the eel, Anguilla japonica. Carbohydr. Res. 338, 263–269. Seidler, D. , Grande‐Allen, K. , Hascall, V. , and Kresse, H. (2002). Core protein dependence of epimerization of glucuronosyl residues in galactosaminoglycans. J. Biol. Chem. 277(44), 42409–42416. Silbert, J. E. (1996). Organization of glycosaminoglycan sulfation in the biosynthesis of proteochondroitin sulfate and proteodermatan sulfate.

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270(13), 7204–7212. , and Kitagawa, H. (2000). Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans. Curr. Opin. Struct. Biol. 10(5), 518–527. , and Yamada, S. (2000). Structure and function of oversulfated chondroitin sulfate variants: Unique sulfation patterns and neuroregulatory activities. Trends Glycosci. Glycotechnol. 12, 321–349. , and Furuhashi, T. (1968). Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion.

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