By Roger G. Pertwee (Ed.), Roger G. Pertwee
The current publication is a phenomenal precis of many elements of cannabinoid study. It presents present wisdom in regards to the pharmacology and healing capability of cannabinoids in addition to wisdom in regards to the pharmacology, body structure, and pathology of the endogenous cannabinoid structures. The chapters are written by way of scientists who've made or are nonetheless making significant contributions to the sphere. This booklet may possibly support generate novel rules on easy methods to procedure the research of emotions.
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Additional resources for Cannabinoids [Handbook of Experimental Pharmacology 168]
Pharmacological Actions of Cannabinoids 29 – It is not sensitive to activation by the established CB1 /CB2 receptor agonists, ∆9 THC, CP55940 or HU-210 (Breivogel et al. 2001; Di Marzo et al. 2000; Monory et al. 2002). – It is not coupled to adenylate cyclase, at least in the cerebellum of CB1 –/– CD1 mice (Monory et al. 2002). – It differs from the CB1 receptor in its central distribution pattern (Breivogel et al. 2001; Monory et al. 2002). – SR141716A and SR144528 do not appear to be competitive antagonists for this putative receptor (Breivogel et al.
This putative receptor for anandamide and R-(+)-WIN55212 appears not to be a TRPV1 receptor (Sect. 1) or to resemble the proposed abnormal-cannabidiol receptor (Sect. 5) as neither of these pharmacological targets is R-(+)-WIN55212-sensitive and as the TRPV1 receptor is not G protein coupled. However, the possibility does remain that it may be a novel metabotropic “vanilloid-like” receptor (see below). The proposed new receptor also differs from established cannabinoid receptors in several ways.
One compound that behaves as a potent agonist at both TRPV1 and CB1 receptors is the synthetic anandamide analogue O-1861 (Fig. 8) (Di Marzo et al. 2001). TRPV1 and CB1 receptors have opposite effects on calcium channel conductance, and there are several reports that in cells such as cultured dorsal root ganglion neurons that co-express these receptors, responses elicited by TRPV1 receptor activation can be opposed by the simultaneous activation of CB1 receptors (Ahluwalia et al. 2003; Ellington et al.