Antiviral Drug Strategies (Methods and Principles in by Erik De Clercq

By Erik De Clercq

Via concentrating on common molecular mechanisms of antiviral medicinal drugs instead of remedies for person viruses, this prepared reference presents the serious wisdom had to boost completely novel therapeutics and to focus on new viruses.It starts off with a basic dialogue of antiviral ideas, via a extensive survey of recognized viral goals, akin to opposite transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, in addition to their identified inhibitors. the ultimate part includes a number of situations stories of modern winning antiviral drug development.Edited through Erik de Clercq, the realm authority on small molecule antiviral medicines, who has built extra new antivirals than an individual else.

Show description

Read Online or Download Antiviral Drug Strategies (Methods and Principles in Medicinal Chemistry, Volume 50) PDF

Best medical ebooks books

Turbomachinery design and theory

No description to be had

Critical Care Nephrology

Internists, surgeons, severe care physicians and nephrologists all deal with seriously sick sufferers with renal failure and the a number of approach organ disorder syndrome. A complete overview of the cutting-edge of this subject is well wanted either in educational and scientific drugs, and important Care Nephrology fulfils this want.

Data Mining in Drug Discovery

Written for drug builders instead of laptop scientists, this monograph adopts a scientific method of mining scientifi c facts assets, masking all key steps in rational drug discovery, from compound screening to guide compound choice and customized drugs. basically divided into 4 sections, the 1st half discusses different information assets to be had, either advertisement and non-commercial, whereas the following part seems to be on the position and cost of knowledge mining in drug discovery.

Assembly Instructions for Polypeptide Models. Academic Press/Molecular Design Inc. Precision Molecular Models

Meeting directions for Polypeptide versions presents meeting systems for? polypeptide chains and for modeling the ? -helix and the parallel and antiparallel ? -pleated sheets. this article is split into 9 chapters and starts off with a short advent to the fundamental unit of polypeptide or protein constitution, that's the amino acid.

Extra info for Antiviral Drug Strategies (Methods and Principles in Medicinal Chemistry, Volume 50)

Example text

Proceedings of the National Academy of Sciences of the United States of America, 97, 7981–7986. , and Llinas-Brunet, M. (2003) An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature, 426, 186–189. A. (2003) Characterization of resistance to nonobligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro. The Journal of Biological Chemistry, 278, 49164–49170. , and Jordan, R. (2005) An orally bioavailable antipoxvirus compound (ST246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus challenge.

Proceedings of the Society for Experimental Biology and Medicine, 109, 251–252. E. and Heidelberger, C. (1964) Therapeutic antiviral action of 5trifluoromethyl-20 -deoxyuridine in herpes simplex keratitis. Science, 145, 585–586. K. (1972) Broad-spectrum antiviral activity of virazole: 1-b-Dribofuranosyl-1,2,4-triazole-3carboxamide. Science, 177, 705–706. , and Houghton, M. (2007) The way forward in HCV treatment: finding the right path. Nature Reviews Drug Discovery, 6, 991–1000. J. (1977) Selectivity of action of an antiherpetic agent, 9-(2hydroxyethoxymethyl)guanine.

Antiviral Research, 75, 30–35. J. (2007) Detection of HSV-1 variants highly resistant to the helicase–primase inhibitor BAY 57-1293 at high frequency in 2 of 10 recent clinical isolates of HSV-1. The Journal of Antimicrobial Chemotherapy, 60, 274–279. J. (2008) A single drugresistance mutation in HSV-1 UL52 primase points to a difference between two helicase–primase inhibitors in their mode of interaction with the antiviral target. The Journal of Antimicrobial Chemotherapy, 61, 1044–1047. De Clercq, E.

Download PDF sample

Rated 4.68 of 5 – based on 22 votes